Our systematic review and meta-analysis of 40 studies (n=3,905,559) identified gastric acid suppressants, recent hospitalization, antibiotic exposure, and certain comorbidities as independent predictors of healthcare-associated Clostridioides difficile infection (HA-CDI) among adult inpatients. Targeted antibiotic stewardship and judicious use of gastric acid suppressants can reduce the incidence of HA-CDI.
Fajnzylber J, Patterson WM, Nero N, et al. Antimicrob Steward Healthc Epidemiol. 2024;4(1):e202. Doi : 10.1017/ash.2024.413. eCollection 2024.